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A term used by the giant-sized Zentradi/Meltrandi to describe humans in terms of their natural height and weight. The term "micloning" refers to the mechanical and biological process through which a full-sized Zentradi/Meltrandi (roughly five times the size of a human) is transformed into a human-sized being. Micloning (also known as Miclonization) is a near-perfected process allowing the Zentradi to change size conveniently and without negatively impacting their mental or physical functions. Both humans and zolans appear able to be macronized through the micloning process (see Macross: Do You Remember Love? and Macross Dynamite 7).

The physical structure of the Zentradi/Meltrandi when in miclone form is almost identical to that of an Earth human. However, when macronized to giant form, the position, function, etc. of their internal organs changes in order to give them a more powerful physical form suitable for battle. It is when macronized by the Miclone System that the Zentradi/Meltrandi unique genetic differences become apparent. During the micloning process the organs and general constitution are scaled up and body-strengthening is applied. Though the Zentradi/Meltrandi are now able to procreate through sexual means as a result of coexistence with humans, many Zentradi/Meltrandi are still created by cloning on Factory Satellites.

In some very rare cases, micloning has resulted in an unfortunate transformation. Due to a genetic anomaly, an adult Meltrandi pilot aboard the Macross Frontier fleet in 2059, experienced unusual side effects from the micloning process which reduced her body to that of an adolescent. The abnormal effects of Klan Klang's genetic anomaly would abate upon returning to giant size and her body would again assume adult proportions.